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1

Expression pattern ofserine protease inhibitor kazal type 3 (Spink3)during mouse embryonic development

Jun Wang, Masaki Ohmuraya, Masahiko Hirota, Hideo Baba, Gang Zhao, Motohiro Takeya, Kimi Araki, Ken-ichi Yamamura

Journal:

Histochemistry and Cell Biology

Year:

2008

Language:

english

File:

PDF, 1.07 MB

english, 2008

2

The role of trypsin, trypsin inhibitor, and trypsin receptor in the onset and aggravation of pancreatitis

Masahiko Hirota, Masaki Ohmuraya, Hideo Baba

Journal:

Journal of Gastroenterology

Year:

2006

Language:

english

File:

PDF, 191 KB

english, 2006

3

Relationship of strain-dependent susceptibility to experimentally induced acute pancreatitis with regulation of Prss1 and Spink3 expression

Wang, Jun, Ohmuraya, Masaki, Suyama, Koichi, Hirota, Masahiko, Ozaki, Nobuyuki, Baba, Hideo, Nakagata, Naomi, Araki, Kimi, Yamamura, Ken-ichi

Journal:

Laboratory Investigation

Year:

2010

Language:

english

File:

PDF, 1.20 MB

english, 2010

4

Significance of endothelial molecular markers in the evaluation of the severity of acute pancreatitis

Satoshi Ida, Yoshinori Fujimura, Masahiko Hirota, Yu Imamura, Nobuyuki Ozaki, Koichi Suyama, Daisuke Hashimoto, Masaki Ohmuraya, Hiroshi Tanaka, Hiroshi Takamori, Hideo Baba

Journal:

Year:

2009

Language:

english

File:

PDF, 284 KB

english, 2009

5

C/EBP homologous protein is crucial for the acceleration of experimental pancreatitis

Koichi Suyama, Masaki Ohmuraya, Masahiko Hirota, Nobuyuki Ozaki, Satoshi Ida, Motoyoshi Endo, Kimi Araki, Tomomi Gotoh, Hideo Baba, Ken-ichi Yamamura

Journal:

Biochemical and Biophysical Research Communications

Year:

2008

Language:

english

File:

PDF, 867 KB

english, 2008

6

Successful coil embolization in an infant with congenital intrahepatic portosystemic shunts

Shinji Ikeda, Yoshihisa Sera, Mituhiro Yoshida, Toshiya Izaki, Shinichiro Uchino, Fumio Endo, Masaki Ohmuraya, Toru Beppu

Journal:

Journal of Pediatric Surgery

Year:

1999

Language:

english

File:

PDF, 1.39 MB

english, 1999

7

Significance of trypsin inhibitor gene mutation in the predisposition to pancreatitis

Masahiko Hirota, Kinuko Kuwata, Masaki Ohmuraya, Michio Ogawa

Journal:

International Congress Series

Year:

2003

Language:

english

File:

PDF, 212 KB

english, 2003

8

Endothelin is involved in pancreatic and intestinal ischemia during severe acute pancreatitis

K. Inoue, M. Hirota, Y. Kimura, K. Kuwata, M. Ohmuraya, M. Ogawa

Journal:

International Congress Series

Year:

2003

Language:

english

File:

PDF, 80 KB

english, 2003

9

The effect of TNF-α converting enzyme inhibitors on cytokine response in acute pancreatitis

Keisuke Maeda, Masahiko Hirota, Yu Kimura, Kotaro Inoue, Kinuko Kuwata, Masaki Ohmuraya, Michio Ogawa

Journal:

International Congress Series

Year:

2003

Language:

english

File:

PDF, 67 KB

english, 2003

10

Dynamic aspects of granulocyte activation in acute pancreatitis

Yu Kimura, Masahiko Hirota, Akihiro Okabe, Kotaro Inoue, Kinuko Kuwata, Masaki Ohmuraya, Michio Ogawa

Journal:

International Congress Series

Year:

2003

Language:

english

File:

PDF, 82 KB

english, 2003

11

c-FLIP Maintains Tissue Homeostasis by Preventing Apoptosis and Programmed Necrosis

Piao, X., Komazawa-Sakon, S., Nishina, T., Koike, M., Piao, J.-H., Ehlken, H., Kurihara, H., Hara, M., Van Rooijen, N., Schutz, G., Ohmuraya, M., Uchiyama, Y., Yagita, H., Okumura, K., He, Y.-W., Naka

Journal:

Science Signaling

Year:

2012

Language:

english

File:

PDF, 2.36 MB

english, 2012

12

910 Transgenic Expression of Pancreatic Secretory Trypsin Inhibitor-I Rescues Spink3 Deficient Mice and Restores a Normal Pancreatic Phenotype

Joelle Romac, Masaki Ohmuraya, Cathy M. Bittner, M. Faraz Majeed, Thomas Wartmann, Ken-ichi Yamamura, Rodger A. Liddle

Journal:

Gastroenterology

Year:

2009

Language:

english

File:

PDF, 66 KB

english, 2009

13

Autophagic Cell Death of Pancreatic Acinar Cells in Serine Protease Inhibitor Kazal Type 3—Deficient Mice

Masaki Ohmuraya, Masahiko Hirota, Masatake Araki, Noboru Mizushima, Makoto Matsui, Takao Mizumoto, Kyoko Haruna, Shoen Kume, Motohiro Takeya, Michio Ogawa, Kimi Araki, Ken—ichi Yamamura

Journal:

Gastroenterology

Year:

2005

Language:

english

File:

PDF, 792 KB

english, 2005

14

Pancreaticodigestive anastomosis and the postoperative management strategies to prevent postoperative pancreatic fistula formation after pancreaticoduodenectomy

Hashimoto, Daisuke, Chikamoto, Akira, Ohmuraya, Masaki, Hirota, Masahiko, Baba, Hideo

Journal:

Year:

2014

Language:

english

File:

PDF, 213 KB

english, 2014

15

Serine protease inhibitor Kazal type 1 and epidermal growth factor receptor are expressed in pancreatic tubular adenocarcinoma, intraductal papillary mucinous neoplasm, and pancreatic intraepithelial neoplasia

Nobuyuki Ozaki, Masaki Ohmuraya, Satoshi Ida…

Journal:

Journal of Hepato-Biliary-Pancreatic Sciences

Year:

2013

Language:

english

File:

PDF, 4.88 MB

english, 2013

16

Su1251 Overexpression of EGFR in the Exocrine Pancreas Induces a Chronic Pancreatitis

Ida, Satoshi, Ohmuraya, Masaki, Baba, Hideo

Journal:

Gastroenterology

Year:

2012

Language:

english

File:

PDF, 182 KB

english, 2012

17

Su1236 Insufficient Levels of Serine Protease Inhibitor Kazal (SPINK) Produced by Partial Expression of SPINK1 in Spink3 Deficient Pancreas Result in Chronic Pancreatitis

Ohmuraya, Masaki, Notohara, Kenji, Araki, Kimi, Hirota, Masahiko, Yamamura, Ken-ichi

Journal:

Gastroenterology

Year:

2012

Language:

english

File:

PDF, 128 KB

english, 2012

18

Autophagic Cell Death of Pancreatic Acinar Cells in Serine Protease Inhibitor Kazal Type 3—Deficient Mice

OHMURAYA, M, HIROTA, M, ARAKI, M, MIZUSHIMA, N, MATSUI, M, MIZUMOTO, T, HARUNA, K, KUME, S, TAKEYA, M, OGAWA, M

Journal:

Gastroenterology

Year:

2005

Language:

english

File:

PDF, 792 KB

english, 2005

19

Autophagy regulation in pancreatic acinar cells is independent of epidermal growth factor receptor signaling

Ozaki, Nobuyuki, Fukuchi, Yuko, Tomiyoshi, Syun-rou, Uehara, Hitoshi, Ida, Satoshi, Wang, Jung, Araki, Kimi, Sibilia, Maria, Baba, Hideo, Yamamura, Ken-ichi, Ohmuraya, Masaki

Journal:

Biochemical and Biophysical Research Communications

Year:

2014

Language:

english

File:

PDF, 1.61 MB

english, 2014

20

Non-Occlusive Mesenteric Ischemia and Its Associated Intestinal Gangrene in Acute Pancreatitis

Hirota, Masahiko, Inoue, Kotaro, Kimura, Yu, Mizumoto, Takao, Kuwata, Kinumo, Ohmuraya, Masaki, Ishiko, Takatoshi, Beppu, Toru, Ogawa, Michio

Journal:

Year:

2003

Language:

english

File:

PDF, 383 KB

english, 2003

21

Autophagic cell death by SPINK insufficiency induces chronic inflammation in the pancreas

Ohmuraya, Masaki, Li, Zhenghua, Yamamura, Ken-ichi

Journal:

Year:

2013

Language:

english

File:

PDF, 46 KB

english, 2013

22

Pancreatic cancer in the remnant pancreas following primary pancreatic resection

Hashimoto, Daisuke, Chikamoto, Akira, Ohmuraya, Masaki, Sakata, Kazuya, Miyake, Keisuke, Kuroki, Hideyuki, Watanabe, Masayuki, Beppu, Toru, Hirota, Masahiko, Baba, Hideo

Journal:

Year:

2014

Language:

english

File:

PDF, 829 KB

english, 2014

23

Involvement of autophagy in trypsinogen activation within the pancreatic acinar cells

Hashimoto, D., Ohmuraya, M., Hirota, M., Yamamoto, A., Suyama, K., Ida, S., Okumura, Y., Takahashi, E., Kido, H., Araki, K., Baba, H., Mizushima, N., Yamamura, K.-i.

Journal:

The Journal of Cell Biology

Year:

2008

Language:

english

File:

PDF, 3.62 MB

english, 2008

24

Impact of Postoperative Weight Loss on Survival After Resection for Pancreatic Cancer

Hashimoto, D., Chikamoto, A., Ohmuraya, M., Abe, S., Nakagawa, S., Beppu, T., Takamori, H., Hirota, M., Baba, H.

Journal:

Journal of Parenteral and Enteral Nutrition

Year:

2015

Language:

english

File:

PDF, 666 KB

english, 2015

25

Genetic background of pancreatitis

Hirota, M., Ohmuraya, M., Baba, H.

Journal:

Postgraduate Medical Journal

Year:

2006

Language:

english

File:

PDF, 167 KB

english, 2006

26

SPINK1 Status in Colorectal Cancer, Impact on Proliferation, and Role in Colitis-Associated Cancer

Ida, S., Ozaki, N., Araki, K., Hirashima, K., Zaitsu, Y., Taki, K., Sakamoto, Y., Miyamoto, Y., Oki, E., Morita, M., Watanabe, M., Maehara, Y., Yamamura, K.-i., Baba, H., Ohmuraya, M.

Journal:

Molecular Cancer Research

Year:

2015

File:

PDF, 868 KB

2015

27

256 p62/SQSTM1 in Pancreatitis Is Regulated Through Both Synthesis and Degradation: Role of mTOR

Pimienta, Michael, Malla, Sudarshan, Lotshaw, Ethan M., Elperin, Jason M., Ohmuraya, Masaki, Mareninova, Olga A., Gukovskaya, Anna S., Gukovsky, Ilya

Journal:

Gastroenterology

Year:

2015

Language:

english

File:

PDF, 128 KB

english, 2015

28

Role of Intrapancreatic SPINK1/Spink3 Expression in the Development of Pancreatitis

Ohmuraya, Masaki, Sugano, Aki, Hirota, Masahiko, Takaoka, Yutaka, Yamamura, Ken-ichi

Journal:

Frontiers in Physiology

Year:

2012

Language:

english

File:

PDF, 1.35 MB

english, 2012

29

Transgenic expression of pancreatic secretory trypsin inhibitor-1 rescues SPINK3-deficient mice and restores a normal pancreatic phenotype

Romac, J. M.-J., Ohmuraya, M., Bittner, C., Majeed, M. F., Vigna, S. R., Que, J., Fee, B. E., Wartmann, T., Yamamura, K.-i., Liddle, R. A.

Journal:

AJP Gastrointestinal and Liver Physiology

Year:

2010

Language:

english

File:

PDF, 2.23 MB

english, 2010

30

Serine Protease Inhibitor Kazal Type 1 Promotes Proliferation of Pancreatic Cancer Cells through the Epidermal Growth Factor Receptor

Ozaki, N., Ohmuraya, M., Hirota, M., Ida, S., Wang, J., Takamori, H., Higashiyama, S., Baba, H., Yamamura, K.-i.

Journal:

Molecular Cancer Research

Year:

2009

Language:

english

File:

PDF, 869 KB

english, 2009

31

GNASR201H and KrasG12D cooperate to promote murine pancreatic tumorigenesis recapitulating human intraductal papillary mucinous neoplasm

Taki, K, Ohmuraya, M, Tanji, E, Komatsu, H, Hashimoto, D, Semba, K, Araki, K, Kawaguchi, Y, Baba, H, Furukawa, T

Journal:

Year:

2015

Language:

english

File:

PDF, 3.15 MB

english, 2015

32

Production of knockout mice by DNA microinjection of various CRISPR/Cas9 vectors into freeze-thawed fertilized oocytes

Nakagawa, Yoshiko, Sakuma, Tetsushi, Sakamoto, Takuya, Ohmuraya, Masaki, Nakagata, Naomi, Yamamoto, Takashi

Journal:

BMC Biotechnology

Year:

2015

Language:

english

File:

PDF, 2.49 MB

english, 2015

33

Involvement of Autophagy in Trypsinogen Activation within the Pancreatic Acinar Cells

Daisuke Hashimoto, Masaki Ohmuraya, Masahiko Hirota, Akitsugu Yamamoto, Koichi Suyama, Satoshi Ida, Yuushi Okumura, Etsuhisa Takahashi, Hiroshi Kido, Kimi Araki, Hideo Baba, Noboru Mizushima and Ken-i

Journal:

The Journal of Cell Biology

Year:

2008

Language:

english

File:

PDF, 2.88 MB

english, 2008

34

Cathepsin D in pancreatic acinar cells is implicated in cathepsin B and L degradation, but not in autophagic activity

Mehanna, Sally, Suzuki, Chigure, Shibata, Masahiro, Sunabori, Takehiko, Imanaka, Takanobu, Araki, Kimi, Yamamura, Ken-ichi, Uchiyama, Yasuo, Ohmuraya, Masaki

Journal:

Biochemical and Biophysical Research Communications

Year:

2016

Language:

english

File:

PDF, 1.77 MB

english, 2016

35

Autophagy and acute pancreatitis: A novel autophagy theory for trypsinogen activation

Ohmuraya, Masaki, Yamamura, Ken-ichi

Journal:

Year:

2008

Language:

english

File:

PDF, 436 KB

english, 2008

36

Autophagy Activates Trypsinogen in Acute Pancreatitis

Ohmuraya, Masaki, Hirota, Masahiko, Hashimoto, Daisuke, Baba, Hideo

Journal:

Year:

2009

Language:

english

File:

PDF, 870 KB

english, 2009

37

CLINICAL PERSPECTIVE OF PANCREATIC CANCER: A RECOLLECTING REPORT FROM THE RECORDS OF OUR DEPARTMENT DURING THE LAST 25 YEARS

Hirota, Masahiko, Nozawa, Fumiaki, Okabe, Akihiro, Shibata, Muneyuki, Inoue, Kotaro, Kimra, Yu, Kuwata, Kinuko, Ohmuraya, Masaki, Maeda, Keisuke, Sugita, Hiroki, Ogawa, Michio

Journal:

Year:

2005

Language:

english

File:

PDF, 160 KB

english, 2005

38

MOLECULAR MECHANISM OF THE DEVELOPMENT AND DETERIORATION OF ACUTE PANCREATITIS

Hirota, Masahiko, Ohmuraya, Masaki, Baba, Hideo

Journal:

Year:

2007

Language:

english

File:

PDF, 560 KB

english, 2007

39

Further Evidence for Endothelin as an Important Mediator of Pancreatic and Intestinal Ischemia in Severe Acute Pancreatitis

Inoue, Kotaro, Hirota, Masahiko, Kimura, Yu, Kuwata, Kinuko, Ohmuraya, Masaki, Ogawa, Michio

Journal:

Year:

2003

Language:

english

File:

PDF, 406 KB

english, 2003

40

Residual total pancreatectomy: Short- and long-term outcomes

Hashimoto, Daisuke, Chikamoto, Akira, Taki, Katsunobu, Arima, Kota, Yamashita, Yo-ichi, Ohmuraya, Masaki, Hirota, Masahiko, Baba, Hideo

Journal:

Year:

2016

Language:

english

File:

PDF, 627 KB

english, 2016

41

687 ATG5 Deficiency Worsens Experimental Pancreatitis in Two Genetic Mouse Models

Malla, Sudarshan R., Qin, Yueqin, Suriany, Silvie, Elperin, Jason M., Lotshaw, Ethan M., Gretler, Sophie, Mareninova, Olga A., Ohmuraya, Masaki, French, Samuel W., Gukovskaya, Anna, Gukovsky, Ilya

Journal:

Gastroenterology

Year:

2016

Language:

english

File:

PDF, 113 KB

english, 2016

42

Dynamic Aspects of Granulocyte Activation in Rat Severe Acute Pancreatitis

Kimura, Yu, Hirota, Masahiko, Okabe, Akihiro, Inoue, Kotaro, Kuwata, Kinuko, Ohmuraya, Masaki, Ogawa, Michio

Journal:

Year:

2003

Language:

english

File:

PDF, 326 KB

english, 2003

43

Successful surgical internal drainage of postoperative pancreatic pseudocyst through pancreaticojejunostomy with distal pancreatectomy: a case report

Sakata, Kazuya, Hashimoto, Daisuke, Taki, Katsunobu, Nakahara, Osamu, Ohmuraya, Masaki, Chikamoto, Akira, Beppu, Toru, Baba, Hideo

Journal:

Surgical Case Reports

Year:

2015

Language:

english

File:

PDF, 2.19 MB

english, 2015

44

Staging laparoscopy leads to rapid induction of chemotherapy for unresectable pancreatobiliary cancers

Hashimoto, Daisuke, Chikamoto, Akira, Sakata, Kazuya, Nakagawa, Shigeki, Hayashi, Hiromitsu, Ohmuraya, Masaki, Hirota, Masahiko, Yoshida, Naoya, Beppu, Toru, Baba, Hideo

Journal:

Asian Journal of Endoscopic Surgery

Year:

2015

Language:

english

File:

PDF, 303 KB

english, 2015

45

Applicability of Disseminated Intravascular Coagulation Parameters in the Assessment of the Severity of Acute Pancreatitis

Maeda, Keisuke, Hirota, Masahiko, Ichihara, Atsushi, Ohmuraya, Masaki, Hashimoto, Daisuke, Sugita, Hiroki, Takamori, Hiroshi, Kanemitsu, Keiichiro, Baba, Hideo

Journal:

Year:

2006

Language:

english

File:

PDF, 149 KB

english, 2006

46

Heterogeneity of KRAS Mutations in Pancreatic Ductal Adenocarcinoma

Hashimoto, Daisuke, Arima, Kota, Yokoyama, Naomi, Chikamoto, Akira, Taki, Katsunobu, Inoue, Risa, Kaida, Takayoshi, Higashi, Takaaki, Nitta, Hidetoshi, Ohmuraya, Masaki, Hirota, Masahiko, Beppu, Toru,

Journal:

Year:

2016

Language:

english

File:

PDF, 342 KB

english, 2016

47

Effect of Low-Molecular Weight Trypsin Inhibitor, Nafamostat Mesilate, on Trypsin Activity Using the Pancreatic Acinar Cells

Hashimoto, Daisuke, Ohmuraya, Masaki, Wang, Jun, Yamamura, Ken-ichi, Hirota, Masahiko, Baba, Hideo

Journal:

Year:

2009

Language:

english

File:

PDF, 1.75 MB

english, 2009

48

Enhanced Trypsin Activity in Pancreatic Acinar Cells Deficient for Serine Protease Inhibitor Kazal Type 3

Ohmuraya, Masaki, Hirota, Masahiko, Araki, Kimi, Baba, Hideo, Yamamura, Ken-ichi

Journal:

Year:

2006

Language:

english

File:

PDF, 2.42 MB

english, 2006

49

Proinflammatory Role of Trypsin and Protease-activated Receptor-2 in a Rat Model of Acute Pancreatitis

Maeda, Keisuke, Hirota, Masahiko, Kimura, Yu, Ichihara, Atsushi, Ohmuraya, Masaki, Sugita, Hiroki, Ogawa, Michio

Journal:

Year:

2005

Language:

english

File:

PDF, 969 KB

english, 2005

50

Short form FLICE-inhibitory protein promotes TNFα-induced necroptosis in fibroblasts derived from CFLARs transgenic mice

Shindo, Ryodai, Yamazaki, Soh, Ohmuraya, Masaki, Araki, Kimi, Nakano, Hiroyasu

Journal:

Biochemical and Biophysical Research Communications

Year:

2016

Language:

english

File:

PDF, 1006 KB

english, 2016